徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
SMURF1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612029 |
| 100ul | WGD-Z-2612029 |
详细参数
| 别名 | E3 ubiquitin-protein ligase SMURF1; hSMURF1; HECT-type E3 ubiquitin transferase SMURF1; SMAD ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1 |
| 基因名 | SMURF1 |
| UniProt ID | Q9HCE7 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6Q2-J8-D8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 86 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:3000-1:4000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | SMAD specific E3 ubiquitin protein ligase 1 (SMURF1) is a HECT-type E3 ubiquitin ligase that serves as a critical negative regulator of the BMP and TGF-beta signaling pathways. It utilizes its N-terminal C2 domain for membrane binding and central WW domains to recognize PY motifs on substrates, while the C-terminal HECT domain facilitates ubiquitin transfer. SMURF1 targets several key signaling proteins for proteasomal degradation, including SMAD1, SMAD4, SMAD5, and SMAD7, as well as various cell surface receptors. Beyond TGF-beta signaling, it regulates cell polarity, migration, and innate immunity by targeting RhoA, Talin, and MAVS. Clinically, dysregulation of SMURF1 is linked to osteoporosis due to excessive inhibition of bone-forming BMP signals, and it is implicated in the pathogenesis of lupus nephritis and certain cancers. |