徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
IL23 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612036 |
| 100ul | WGD-Z-2612036 |
详细参数
| 别名 | Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19 |
| 基因名 | IL23 |
| UniProt ID | Q9NPF7 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3R3-A8-R7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 20 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Interleukin 23 subunit alpha (IL23) is a four-helix bundle cytokine that heterodimerizes with the p40 subunit of IL-12 to form the functional IL-23 cytokine complex. Produced primarily by activated dendritic cells and macrophages, IL-23 plays a pivotal role in the maintenance and expansion of Th17 cells, which produce IL-17 and other pro-inflammatory mediators. The interaction between the alpha subunit and p40 is stabilized by a unique disulfide bond and a conserved arginine pocket interface. IL-23 signaling promotes chronic inflammation, angiogenesis, and the inhibition of regulatory T cells, thereby bridging innate and adaptive immunity. Clinically, IL-23 is a major therapeutic target in autoimmune and inflammatory diseases, including psoriasis, inflammatory bowel disease, and rheumatoid arthritis, where its overexpression drives Th17-mediated tissue pathology. |