徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
ACP6 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612037 |
| 100ul | WGD-Z-2612037 |
详细参数
| 别名 | Lysophosphatidic acid phosphatase type 6; Acid phosphatase 6; lysophosphatidic; Acid phosphatase-like protein 1; PACPL1 |
| 基因名 | ACP6 |
| UniProt ID | Q9NPH0 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4U4-U1-O2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 48 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Acid phosphatase 6, lysophosphatidic (ACP6) is a mitochondrial phosphomonoesterase that specifically hydrolyzes lysophosphatidic acid (LPA) into monoacylglycerol and free phosphate. It exhibits a preference for LPA substrates with medium-length fatty acid chains and functions optimally at low pH. By regulating the levels of LPA, ACP6 modulates downstream signaling through G protein-coupled receptors that control cell growth, proliferation, and wound healing. The enzyme's structure includes a hydrophilic water channel and an active site stabilized by specific arginine and histidine residues. Clinically, ACP6 is frequently downregulated in ovarian cancer, often as a result of gain-of-function p53 mutations. This loss of ACP6 leads to elevated LPA levels, which drive focal adhesion signaling, increased cell motility, and metastasis, marking it as a significant factor in tumor progression. |