徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
MRGBP Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612056 |
| 100ul | WGD-Z-2612056 |
详细参数
| 别名 | MRG/MORF4L-binding protein; MRG-binding protein; Up-regulated in colon cancer 4; Urcc4 |
| 基因名 | MRGBP |
| UniProt ID | Q9NV56 |
| 反应种属 | Human,Mouse |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2U6-F7-C2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 22 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | MRG domain binding protein (MRGBP) is a nuclear subunit of the NuA4/TRRAP-TIP60 histone acetyltransferase complex, which regulates chromatin structure and gene expression by acetylating histones H4 and H2A. Through its role in the NuA4 complex, MRGBP participates in transcriptional programs related to cell proliferation, DNA repair, and apoptosis. It specifically modulates DNA double-strand break repair by limiting DNA-end resection, thereby restraining homologous recombination and non-homologous end joining to maintain genome stability. Clinically, MRGBP is overexpressed in several malignancies and has been proposed as a prognostic biomarker in head and neck squamous cell carcinoma, where high expression levels correlate with poor clinical outcomes. |