徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CZIB Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612068 |
| 100ul | WGD-Z-2612068 |
详细参数
| 别名 | CXXC motif containing zinc binding protein; UPF0587 protein C1orf123 |
| 基因名 | CZIB |
| UniProt ID | Q9NWV4 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7Z8-H9-N2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 18 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | CXXC motif containing zinc binding protein (CZIB) is a small, evolutionarily conserved intracellular protein characterized by two canonical Cys-X-X-Cys (CXXC) motifs. These motifs facilitate the tetrahedral coordination of a zinc ion via four cysteine thiolates, which is essential for the protein's structural integrity and function. CZIB specifically interacts with the heavy-metal-associated (HMA) domain of the copper chaperone for superoxide dismutase (CCS). This interaction requires intact CXXC motifs in both partners, suggesting that CZIB plays a specialized role in metal-mediated protein-protein interactions and intracellular metal handling. As a soluble protein lacking transmembrane domains, CZIB is primarily involved in zinc and protein binding within the cytosol. Its conserved nature across species underscores its importance in maintaining metal homeostasis and supporting the functional assembly of metal-dependent chaperone complexes. |