徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
SMPD3 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612071 |
| 100ul | WGD-Z-2612071 |
详细参数
| 别名 | Sphingomyelin phosphodiesterase 3; Neutral sphingomyelinase 2; nSMase-2; nSMase2; Neutral sphingomyelinase II |
| 基因名 | SMPD3 |
| UniProt ID | Q9NY59 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7D2-E4-R7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 71 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000; IHC-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Sphingomyelin phosphodiesterase 3 (SMPD3), also known as neutral sphingomyelinase 2, is an enzyme encoded by the SMPD3 gene in humans. This protein plays a critical role in sphingolipid metabolism by catalyzing the hydrolysis of sphingomyelin to generate ceramide and phosphocholine, a process pivotal for regulating cellular functions such as apoptosis, cell cycle arrest, and growth control. SMPD3 is involved in several metabolic pathways, including ceramide signaling, glycosphingolipid metabolism, and lipid and lipoprotein metabolism, highlighting its importance in maintaining cellular lipid homeostasis. Structurally, SMPD3 shares a conserved catalytic domain with other sphingomyelinases, and its activity is essential for multicellular organism development and the positive regulation of ceramide biosynthesis. Dysregulation or mutations in SMPD3 have been associated with pathological conditions such as necrosis and may contribute to broader metabolic or developmental disorders. |