徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
MAT2B Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612077 |
| 100ul | WGD-Z-2612077 |
详细参数
| 别名 | Methionine adenosyltransferase 2 subunit beta; Methionine adenosyltransferase II beta; MAT II beta; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase |
| 基因名 | MAT2B |
| UniProt ID | Q9NZL9 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 3U9-R9-L4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 37 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Methionine adenosyltransferase 2 non-catalytic beta subunit (MAT2B) is a regulatory subunit of the cytosolic S-adenosylmethionine synthetase 2 (MAT2A) complex. While MAT2B lacks independent catalytic activity, it modulates the kinetics of MAT2A by increasing its affinity for L-methionine and influencing feedback sensitivity to S-adenosylmethionine (SAM). Structurally, MAT2B adopts a short-chain dehydrogenase/reductase-like fold and binds NADP(H), which stabilizes the MAT2A protein and links cellular redox status to SAM production and RNA m6A methylation. This regulatory mechanism is vital for maintaining the methyl donor pool required for diverse cellular processes. Clinically, MAT2B is broadly expressed in proliferative tissues and its overexpression has been implicated in supporting the metabolic demands of tumor growth. |