徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
DNMT3B Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612096 |
| 100ul | WGD-Z-2612096 |
详细参数
| 别名 | DNA; cytosine-5)-methyltransferase 3B; Dnmt3b; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; M.HsaIIIB |
| 基因名 | Dnmt3b |
| UniProt ID | Q9UBC3 |
| 反应种属 | Human,Mouse |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 3Q6-V5-S9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 95 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | DNA methyltransferase 3 beta (Dnmt3b) is an enzyme essential for establishing de novo DNA methylation patterns during mammalian embryonic development. It catalyzes the transfer of methyl groups to cytosine residues in CpG dinucleotides, a process critical for gene silencing and genomic stability. DNMT3B contains a PWWP domain that guides it to specific chromatin regions by binding H3K36me3 marks. It functions cooperatively with DNMT3A and DNMT3L. Pathogenic mutations in DNMT3B cause immunodeficiency-centromere instability-facial anomalies (ICF) syndrome, a disorder characterized by hypomethylation of pericentromeric heterochromatin, immune defects, and developmental abnormalities. |