徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
TES Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612104 |
| 100ul | WGD-Z-2612104 |
详细参数
| 别名 | Testin; TESS |
| 基因名 | TES |
| UniProt ID | Q9UGI8 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6V3-M3-N7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 47 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Testin LIM domain protein (TES) is a cytoskeletal scaffold protein comprising an N-terminal PET domain and three C-terminal LIM zinc-finger domains. It localizes to focal adhesions and actin stress fibers, where it regulates cell spreading, motility, and cytoskeletal reorganization. Functioning as a tumor suppressor, TES negatively regulates cell proliferation and is frequently silenced in malignancies—including ovarian, breast, and gastric cancers—via promoter hypermethylation and loss of heterozygosity. Reduced TES expression correlates with epithelial-mesenchymal transition (EMT) and poor prognosis, suggesting its potential utility as a biomarker for cancer progression and therapeutic response. |