徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
STOML2 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612122 |
| 100ul | WGD-Z-2612122 |
详细参数
| 别名 | Stomatin-like protein 2; mitochondrial; SLP-2; EPB72-like protein 2; Paraprotein target 7; Paratarg-7 |
| 基因名 | STOML2 |
| UniProt ID | Q9UJZ1 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9L8-W2-K5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 38 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Stomatin like 2 (STOML2) is a mitochondrial inner membrane protein belonging to the SPFH superfamily that plays a vital role in mitochondrial biogenesis and function. It binds cardiolipin to form specialized membrane microdomains that recruit prohibitins, optimizing the assembly of the respiratory chain complex and regulating calcium homeostasis. STOML2 also anchors the SPY protease complex for mitochondrial quality control. Beyond the mitochondria, it localizes to plasma membrane rafts in T cells, where it facilitates T cell receptor signaling and activation. Clinically, STOML2 is frequently overexpressed in various malignancies, including hepatocellular carcinoma and breast cancer, where it promotes cell proliferation, resistance to apoptosis, and metastasis, often correlating with a poor clinical prognosis. |