徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
ING1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612123 |
| 100ul | WGD-Z-2612123 |
详细参数
| 别名 | Inhibitor of growth protein 1 |
| 基因名 | ING1 |
| UniProt ID | Q9UK53 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IP,CHIP,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 9Y6-Z4-V2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 46 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Inhibitor of growth family member 1 (ING1) is a tumor suppressor protein that plays a crucial role in regulating cell growth, apoptosis, and senescence. It is encoded by the ING1 gene located on chromosome 13q34 and is characterized by its ability to induce cell growth arrest and apoptosis through interactions with the tumor suppressor protein TP53 and other proteins such as PCNA and HDAC1. ING1 has multiple isoforms, including ING1a and ING1b, which are widely expressed and particularly high in testes and thymus, respectively. Reduced expression and rearrangement of ING1 have been associated with various cancers, including head and neck squamous cell carcinoma, breast cancer, lung cancer, and gastric cancer. ING1's role in tumor suppression involves epigenetic regulation, affecting cancer hallmarks such as sustained cell proliferation and evasion of apoptosis. |