徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
SIGLEC9 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612170 |
| 100ul | WGD-Z-2612170 |
详细参数
| 别名 | Sialic acid-binding Ig-like lectin 9; Siglec-9; CDw329; Protein FOAP-9; CD antigen CD329 |
| 基因名 | SIGLEC9 |
| UniProt ID | Q9Y336 |
| 反应种属 | Human,Mouse |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 2J6-Y6-F7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 50 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Sialic acid binding Ig like lectin 9 (SIGLEC9) is a transmembrane protein belonging to the immunoglobulin superfamily, characterized by an N-terminal Ig-like V-type domain responsible for sialic acid binding, followed by two Ig-like C2-type domains, a transmembrane region, and a cytoplasmic tail. The protein consists of 463 amino acids and is predominantly expressed on neutrophils, monocytes, a subset of NK cells, B cells, and some CD8+ T cells. SIGLEC9 mediates sialic acid-dependent cell adhesion, binding preferentially and equally to both α2,3- and α2,6-linked sialic acids, and is closely related to SIGLEC7, sharing about 80% sequence identity. Functionally, it is involved in cell-cell interactions and immune modulation through its carbohydrate-binding activity. Clinically, SIGLEC9 has been implicated in immune regulation and is associated with inflammatory and autoimmune diseases, as its expression and function can influence immune cell signaling and inflammatory responses. |