Overview
| 别名 | Antigen NY-CO-9; HD5; Histone deacetylase 5; Histone deacetylase mHDA1; KIAA0600 |
| 基因名 | HDAC5 |
| UniProt ID | Q9UQL6 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IHC-P,ICC/IF,ELISA |
| 宿主 | Rabbit |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG |
| 克隆性 | Polyclonal Antibody |
| 分子量 | Calculated MW: 122 kDa; Observed MW: 122 kDa |
| 纯化方式 | Affinity Chromatography |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:500-1:2000; IHC-1:100-1:300; IF-1:200-1:1000; ELISA-1:20000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. |
检测原理