Overview
| 别名 | MCT-1; Multiple copies T-cell malignancies |
| 基因名 | MCTS1 |
| UniProt ID | Q9ULC4 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Rabbit |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG |
| 克隆性 | Polyclonal Antibody |
| 分子量 | Calculated MW: 21 kDa; Observed MW: 21 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:500-1:1000; IHC-1:50-1:100 |
| 存储缓冲液 | Liquid in pH 7.4 PBS, 0.05% NaN3, 40% Glycerol |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation (PubMed:16982740, PubMed:20713520, PubMed:37875108). |
检测原理