Overview
| 别名 | DGCR8; DGCRK6; Gy1; C22orf12; D16Wis2; pasha; DGCRK6; C22orf12; D16H22S788E; |
| 基因名 | DGCR8 |
| UniProt ID | Q8WYQ5 |
| 反应种属 | Human,Mouse,Rat |
| 应用 | WB,ICC/IF,FC,IP |
| 宿主 | Rabbit |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG |
| 克隆号 | R04-9G-6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 86 kDa; Observed MW: 100 kDa |
| 纯化方式 | Affinity Chromatography |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:500-1:1000; ICC/IF-1:500-1:1000; FC-1:200-1:1000; IP-1:20-1:50 |
| 存储缓冲液 | Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. |
检测原理