Overview
| 别名 | CDw156; CD156c; ADAM10; KUZ; MADM; ADAM 10; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease |
| 基因名 | ADAM10 |
| UniProt ID | O14672 |
| 反应种属 | Human,Mouse,Rat |
| 应用 | WB,IP |
| 宿主 | Rabbit |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG |
| 克隆号 | R01-2I-7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 84 kDa; Observed MW: 90,68 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000-1:5000; IP-1:10-1:100 |
| 存储缓冲液 | Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | The ADAM10 prodomain acts as a chaperone that stabilizes mature ADAM protein folding, and prevents target-protein shedding through inhibition of ADAM10 proteinase activity. Mature ADAM10 is the major α-secretase responsible for cleavage of Notch, APP, cadherins, and prion protein. The ADAM10 protein cleaves receptor tyrosine kinases and their associated ligands and displays a wide range of regulatory functions across related signaling pathways. |
检测原理