Overview
| 别名 | Protein FAM186A |
| 基因名 | FAM186A |
| UniProt ID | A6NE01 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5G9-H8-D8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 262 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Family with sequence similarity 186 member A (FAM186A) is a protein-coding gene located on chromosome 12 that encodes a protein of defined structural domains but uncharacterized specific molecular function. Expression profiling indicates cell cycle-dependent localization to mitotic and interphase structures, with presence in specific brain regions such as the hippocampus and cerebral cortex, as well as in the gastrointestinal tract and endocrine glands. Although its precise biological role remains under investigation, bioinformatic and experimental data suggest involvement in fundamental cellular processes. Clinically, FAM186A has been linked to Fanconi Anemia, Complementation Group E, a disorder of DNA repair and bone marrow failure, and is associated with cerebral atherosclerosis, implicating it in genomic stability and vascular pathology. |
检测原理