Overview
| 别名 | E3 ubiquitin-protein ligase RNF212B; RING finger protein 212B |
| 基因名 | RNF212B |
| UniProt ID | A8MTL3 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7N4-P7-N5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 33 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Ring finger protein 212B (RNF212B) is a RING E3 ubiquitin ligase essential for meiotic progression. During prophase I of meiosis, it functions to designate and mature crossover sites, ensuring proper chromosome segregation and fertility. RNF212B localizes to the central region of the synaptonemal complex, where it cooperates with its paralog RNF212 and other factors like HEI10 to stabilize specific recombination intermediates. Its ubiquitin ligase activity is critical for the transformation of these intermediates into mature crossovers. Loss of RNF212B function leads to defects in crossover formation and sterility, although specific human disease associations remain to be robustly defined. |
检测原理