Overview
| 别名 | Syntaxin-binding protein 3; Platelet Sec1 protein; PSP; Protein unc-18 homolog 3; Unc18-3; Protein unc-18 homolog C; Unc-18C |
| 基因名 | STXBP3 |
| UniProt ID | O00186 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 8I3-U2-P9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 67 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Syntaxin binding protein 3 (STXBP3), also known as Munc18c, is a cytosolic protein that regulates membrane fusion by binding to syntaxin 3 (STX3), a Qa-SNARE protein involved in vesicle docking and exocytosis. STXBP3 interacts specifically with syntaxins to control SNARE complex assembly, essential for processes like insulin-stimulated GLUT4 vesicle fusion in adipocytes and muscle cells, thereby regulating glucose uptake. Structurally, STXBP3 modulates syntaxin conformation, influencing vesicle trafficking and exocytosis efficiency. It also plays roles in neutrophil degranulation and platelet aggregation by negatively regulating calcium-dependent exocytosis. Importantly, STXBP3-mediated regulation of vesicle fusion impacts insulin secretion and glucose homeostasis, linking it to metabolic disorders such as type 2 diabetes. Additionally, its interaction with ubiquitin and involvement in endosomal trafficking suggest broader roles in membrane protein sorting. Dysregulation of STXBP3 function can impair insulin secretion and vesicle trafficking, contributing to metabolic disease pathogenesis. |
检测原理