Overview
| 别名 | AP-3 complex subunit beta-1; Adaptor protein complex AP-3 subunit beta-1; Adaptor-related protein complex 3 subunit beta-1; Beta-3A-adaptin; Clathrin assembly protein complex 3 beta-1 large chain |
| 基因名 | AP3B1 |
| UniProt ID | O00203 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6O2-J7-W3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 121 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Adaptor related protein complex 3 subunit beta 1 (AP3B1) is the beta subunit of the heterotetrameric AP-3 adaptor complex, which is essential for the sorting of transmembrane proteins to lysosome-related organelles. It facilitates vesicle budding from the trans-Golgi network and endosomes, directing cargo to destinations such as melanosomes and platelet dense granules. AP3B1 is critical for organelle biogenesis and function. Pathogenic loss-of-function mutations in AP3B1 result in Hermansky-Pudlak syndrome type 2 (HPS2), a disorder characterized by oculocutaneous albinism, bleeding diathesis due to platelet storage pool deficiency, and neutropenia, reflecting the widespread failure of lysosomal and granule trafficking pathways. |
检测原理