Overview
| 别名 | NF-kappa-B inhibitor epsilon; NF-kappa-BIE; I-kappa-B-epsilon; IkB-E; IkB-epsilon; IkappaBepsilon |
| 基因名 | NFKBIE |
| UniProt ID | O00221 |
| 反应种属 | Human |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6K4-J8-J6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 52 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | NFKB inhibitor epsilon (NFKBIE), or Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, is a protein that inhibits the NF-κB transcription factor complex by trapping it in the cytoplasm. This protein is encoded by the NFKBIE gene located on chromosome 6 in humans. NFKBIE binds to components of NF-κB, preventing it from activating genes in the nucleus. The NF-κB complex is crucial for various cellular processes, including immune responses and inflammation. NFKBIE's expression is up-regulated following NF-κB activation and during myelopoiesis, indicating its role in regulating NF-κB activity. NFKBIE interacts with NFKB2, RELA, NFKB1, and REL, further emphasizing its role in modulating NF-κB signaling. The function of NFKBIE in regulating NF-κB activity suggests its potential involvement in conditions related to immune dysregulation and inflammation. |
检测原理