Overview
| 别名 | Bone morphogenetic protein receptor type-1B; BMP type-1B receptor; BMPR-1B; CD antigen CDw293 |
| 基因名 | BMPR1B |
| UniProt ID | O00238 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9J2-X8-X1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 56 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Bone Morphogenetic Protein Receptor Type 1B (BMPR1B) is a transmembrane serine/threonine kinase receptor that plays a crucial role in the bone morphogenetic protein (BMP) signaling pathway. It is involved in various biological processes, including embryogenesis, tissue homeostasis, and disease progression. BMPR1B is predominantly expressed in embryonic tissues, skeletal structures, and reproductive organs, and it signals through Smad-dependent and Smad-independent pathways to regulate gene expression, cellular proliferation, differentiation, and apoptosis. Mutations in the BMPR1B gene have been associated with several diseases, including acromesomelic dysplasia, brachydactyly type A1, and primary pulmonary hypertension. |
检测原理