Overview
| 别名 | NEDD4-like E3 ubiquitin-protein ligase WWP2; Atrophin-1-interacting protein 2; AIP2; HECT-type E3 ubiquitin transferase WWP2; WW domain-containing protein 2 |
| 基因名 | WWP2 |
| UniProt ID | O00308 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 9B7-J2-C2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 98 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2) is an E3 ubiquitin ligase that plays a crucial role in various biological processes, including protein ubiquitination, chondrogenesis, and oncogenic signaling pathways. It interacts with Smad proteins and the tumor suppressor PTEN, influencing cell signaling and differentiation. WWP2 has been linked to several diseases, including Spondyloepiphyseal Dysplasia, Nishimura Type, and Cowden Syndrome 1, and its dysregulation can contribute to fibrosis, inflammation, and cancer progression. The inhibition of WWP2 has been identified as a potential therapeutic strategy for treating diseases characterized by fibrosis and inflammation, as it regulates the expression of pro-inflammatory factors and fibroblast activation. Additionally, WWP2 isoforms have distinct functions, with WWP2-N potentially suppressing TGFβ-induced epithelial-to-mesenchymal transition (EMT) and WWP2-C interacting with inhibitory Smad7. |
检测原理