Overview
| 别名 | Protein Wnt-7a |
| 基因名 | WNT7A |
| UniProt ID | O00755 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 7D5-X5-E7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 39 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Wnt family member 7A (WNT7A) is a secreted signaling protein of the Wnt family that functions as a ligand for Frizzled receptors to activate the canonical beta-catenin signaling pathway. It plays a morphogenic role during embryonic development, governing the dorsal-ventral patterning of limbs and the anterior-posterior axis of the female reproductive tract. WNT7A is also crucial for the formation of the blood-brain barrier and synaptic maturation. Mutations in WNT7A cause severe limb malformation syndromes, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia, characterized by skeletal defects such as the absence of long bones. Additionally, WNT7A signaling is implicated in uterine smooth muscle patterning and tumorigenesis. |
检测原理