Overview
| 别名 | Spectrin beta chain; non-erythrocytic 2; Beta-III spectrin; Spinocerebellar ataxia 5 protein |
| 基因名 | SPTBN2 |
| UniProt ID | O15020 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7Q2-V5-V6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 271 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Spectrin beta, non-erythrocytic 2 (SPTBN2) is a major component of the neuronal membrane cytoskeleton. It forms heterodimers with alpha-spectrin to stabilize the plasma membrane and organize synaptic signaling complexes, specifically regulating the localization of the glutamate transporter EAAT4. SPTBN2 binds actin and phospholipids, essential for maintaining neuronal structural integrity and dendritic morphology. Pathogenic mutations in SPTBN2 cause Spinocerebellar Ataxia type 5 (SCA5) and Autosomal Recessive Spinocerebellar Ataxia 14 (SCAR14). These neurodegenerative disorders are characterized by progressive motor incoordination, dysarthria, and Purkinje cell loss, highlighting the critical role of SPTBN2 in cerebellar function. |
检测原理