Overview
| 别名 | Microtubule-associated serine/threonine-protein kinase 4 |
| 基因名 | MAST4 |
| UniProt ID | O15021 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1D9-O3-H6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 284 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Microtubule-associated serine/threonine-protein kinase 4 (MAST4) is a serine/threonine kinase that plays a significant role in various cellular processes, particularly in the regulation of cell signaling pathways involved in differentiation and development. MAST4 is primarily associated with microtubules and is implicated in the modulation of cytoskeletal dynamics, influencing cell shape and motility. Research has shown that MAST4 is essential for the differentiation of mesenchymal stem cells (MSCs) into chondrocytes and osteoblasts by mediating signaling pathways such as TGF-β and Wnt. Dysregulation of MAST4 expression has been linked to diseases such as osteoarthritis and osteoporosis, where its altered activity can disrupt normal bone and cartilage formation. Additionally, MAST4's involvement in cellular signaling suggests potential implications in cancer progression, where it may affect tumor cell behavior. |
检测原理