Overview
| 别名 | Glutathione S-transferase A4; GST class-alpha member 4; Glutathione S-transferase A4-4 |
| 基因名 | GSTA4 |
| UniProt ID | O15217 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2B7-E6-Z3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 25 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Glutathione S-transferase alpha 4 (GSTA4) is a phase II detoxifying enzyme involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. It catalyzes the conjugation of reduced glutathione to a wide range of exogenous and endogenous hydrophobic electrophiles, with high efficiency for 4-hydroxynonenal (4-HNE). GSTA4 is expressed in various tissues, including liver, kidney, and brain, and plays a crucial role in protecting cells from oxidative stress. The enzyme is encoded by the GSTA4 gene located on chromosome 6 in humans. GSTA4 has been implicated in several diseases, including Parkinson's disease, Alzheimer's disease, and atherosclerosis. Decreased expression of GSTA4 has been observed in burn and trauma victims, while increased expression has been noted in colorectal cancer. |
检测原理