Overview
| 别名 | Short stature homeobox protein; Pseudoautosomal homeobox-containing osteogenic protein; Short stature homeobox-containing protein |
| 基因名 | SHOX |
| UniProt ID | O15266 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4T6-Z1-P3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 32 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | SHOX homeobox (SHOX) is transcription factor critical for skeletal development, particularly in the arms and legs. It regulates cell proliferation and differentiation in bone progenitor cells, maintaining their undifferentiated state while suppressing early osteogenic gene expression. SHOX protein functions as both an activator and repressor of target genes and is expressed in diverse tissues, including human mesenchymal stem cells (hMSCs). Knockdown studies in zebrafish embryos and hMSCs reveal its essential role in bone growth, with deficiencies leading to reduced proliferation and premature differentiation of skeletal progenitors. Mutations or deletions of SHOX are linked to disorders like Léri-Weill dyschondrosteosis and Turner syndrome, characterized by short stature and skeletal abnormalities such as Madelung deformity. These conditions arise from disrupted SHOX activity, impairing normal bone development. |
检测原理