Overview
| 别名 | Syntaxin-7 |
| 基因名 | STX7 |
| UniProt ID | O15400 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6J1-I2-E4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 29 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Syntaxin-7 (STX7) is a member of the syntaxin family of proteins, which are integral components of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex involved in membrane fusion processes. STX7 is primarily localized to endosomal membranes and plays a crucial role in mediating vesicle trafficking and fusion within the endosomal-lysosomal pathway. Its function is essential for the recycling of synaptic vesicles and the delivery of cargo to lysosomes. Dysregulation or mutations in STX7 have been associated with several diseases, including Hermansky-Pudlak syndrome, characterized by oculocutaneous albinism and bleeding disorders due to impaired lysosomal function. Additionally, STX7 has been implicated in neurodegenerative diseases, such as Alzheimer's disease, where its dysfunction may contribute to amyloid-beta accumulation. |
检测原理