Overview
| 别名 | DNA-directed RNA polymerase I subunit RPA34; A34.5; Antisense to ERCC-1 protein; ASE-1; CD3-epsilon-associated protein; CD3E-associated protein; DNA-directed RNA polymerase I subunit G; RNA polymerase I-associated factor PAF49 |
| 基因名 | POLR1G |
| UniProt ID | O15446 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4A1-Q3-O7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 54 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | RNA polymerase I subunit G (POLR1G), also known as RPA34, is an essential component of the RNA polymerase I complex. It is responsible for the synthesis of ribosomal RNA precursors from DNA templates, a fundamental step in ribosome biogenesis. POLR1G facilitates transcription initiation at the RNA polymerase I promoter by promoting the formation of the pre-initiation complex and enabling RNA binding. The protein localizes to the nucleolus, nuclear lumen, and mitochondria, participating in pathways related to promoter opening and transcription termination. Clinically, mutations in POLR1G are linked to Cerebrooculofacioskeletal Syndrome 4, a severe neurodevelopmental disorder characterized by microcephaly, congenital cataracts, and progressive neurological degeneration. These symptoms arise from defective nucleotide excision repair and impaired transcription. Additionally, POLR1G has been associated with aggressive malignancies such as hepatoid adenocarcinoma and multiple myeloma. |
检测原理