Overview
| 别名 | Cone-rod homeobox protein |
| 基因名 | CRX |
| UniProt ID | O43186 |
| 反应种属 | Human |
| 应用 | IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 1B3-O3-X1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 32 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Cone-rod homeobox protein (CRX) is a transcription factor essential for the development and maintenance of photoreceptor cells in the retina, specifically rods and cones, which are critical for vision. Characterized by its homeodomain, CRX binds to specific DNA sequences to regulate genes involved in phototransduction and photoreceptor cell differentiation. Mutations in the CRX gene are associated with various inherited retinal diseases, including retinitis pigmentosa, cone-rod dystrophy, and Leber congenital amaurosis, leading to progressive vision loss. These mutations often result in reduced or dysfunctional CRX protein, impairing the transcriptional regulation necessary for photoreceptor survival and function. The severity of vision impairment can vary significantly among individuals with CRX mutations, indicating the influence of additional genetic or environmental factors. |
检测原理