Overview
| 别名 | Sialic acid-binding Ig-like lectin 6; Siglec-6; CD33 antigen-like 1; CDw327; Obesity-binding protein 1; OB-BP1; CD antigen CD327 |
| 基因名 | SIGLEC6 |
| UniProt ID | O43699 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4D2-T5-R7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 49 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Sialic acid-binding Ig-like lectin 6 (SIGLEC6) is a transmembrane protein belonging to the SIGLEC family, primarily expressed in placenta, mast cells, and memory B-cells. It functions as an immunoreceptor that binds sialyl-TN glycans and leptin, playing a role in cell adhesion and migration, particularly in chronic lymphocytic leukemia (CLL). In CLL, SIGLEC6 is implicated in the interaction of B-cells with bone marrow stromal cells, affecting their migration and survival. Dysregulation of SIGLEC6 is associated with diseases such as indolent systemic mastocytosis and gestational trophoblastic disease, where it contributes to aberrant cellular proliferation and invasion. Its potential as a therapeutic target is underscored by studies indicating that SIGLEC6 engagement can enhance immune responses against cancer cells. |
检测原理