Overview
| 别名 | Xaa-Pro aminopeptidase 2; Aminoacylproline aminopeptidase; Membrane-bound aminopeptidase P; Membrane-bound APP; Membrane-bound AmP; mAmP; X-Pro aminopeptidase 2 |
| 基因名 | XPNPEP2 |
| UniProt ID | O43895 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2Z7-B1-M7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 75 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | X-prolyl aminopeptidase 2 (XPNPEP2) is a membrane-bound metalloprotease that catalyzes the removal of penultimate prolyl residues from N-termini of peptides, such as Arg-Pro-Pro. It belongs to the M24 family of metalloproteases and is widely expressed in human tissues, with highest levels in the kidney. XPNPEP2 is a GPI-anchored protein with 674 amino acids and plays a role in the metabolism of bioactive peptides like bradykinin. The enzyme is involved in proteolysis and has metal ion binding and metalloaminopeptidase activities. XPNPEP2 has been associated with several diseases, including angioedema, experimental liver cirrhosis, and primary ovarian insufficiency. Recent studies have also linked XPNPEP2 to cancer progression, with overexpression observed in cervical cancer and association with lymph node metastasis in prostate cancer patients. |
检测原理