Overview
| 别名 | Kinesin-like protein KIF1C |
| 基因名 | KIF1C |
| UniProt ID | O43896 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7A1-R5-U4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 122 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Kinesin family member 1C (KIF1C) is a plus-end-directed microtubule motor belonging to the kinesin-3 family, primarily involved in the transport of Golgi- and endosome-derived vesicles. It functions as a stable homodimer featuring an N-terminal ATP-dependent motor domain and a forkhead-associated (FHA) domain that facilitates interactions with cargo and regulatory proteins. KIF1C is essential for maintaining Golgi ribbon organization and participates in bidirectional transport through functional coupling with dynein-dynactin adapters such as HOOK3 and BICDR1. It is highly expressed in the brain and immune cells, where it supports critical intracellular trafficking pathways. Clinically, pathogenic biallelic variants in KIF1C are the cause of a spectrum of neurodegenerative disorders, including autosomal recessive hereditary spastic paraplegia and spinocerebellar ataxia type 58, characterized by progressive spastic paraparesis and cerebellar ataxia. |
检测原理