Overview
| 别名 | Uncharacterized protein KIAA0513 |
| 基因名 | KIAA0513 |
| UniProt ID | O60268 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7Q7-J7-J1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 46 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | KIAA0513 encodes a cytoplasmic protein predominantly expressed in the brain, with enrichment in the cerebellum, hippocampus, and cortex. Although it lacks defined catalytic domains, it functions as a signaling scaffold, interacting with proteins such as KIBRA and HAX-1 to regulate neuroplasticity, apoptosis, and cytoskeletal organization. KIAA0513 is implicated in synaptic homeostasis and cognitive pathways. Clinically, altered expression or genetic variants are associated with neurodevelopmental and neuropsychiatric conditions, including autism spectrum disorder and schizophrenia. Furthermore, it has been identified as a hub gene in Alzheimer’s disease networks, correlating with beta-amyloid pathology and synaptic dysfunction. |
检测原理