Overview
| 别名 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1; Brain cyclic nucleotide-gated channel 1; BCNG-1 |
| 基因名 | HCN1 |
| UniProt ID | O60741 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9A8-Q2-R7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 98 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Hyperpolarization activated cyclic nucleotide gated potassium channel 1 (HCN1) is a membrane cation channel that mediates the hyperpolarization-activated funny current (Ih), a key driver of pacemaker activity and rhythmic firing in neurons and cardiomyocytes. The channel functions as a homo- or heterotetramer and interacts with auxiliary subunits such as KCNE2 to modulate gating kinetics. Structurally, HCN1 features a six-transmembrane voltage-gated potassium channel-like architecture with a C-terminal cyclic nucleotide-binding domain. Binding of cAMP to this domain shifts channel activation toward more depolarized potentials, enhancing excitability. In the nervous system, HCN1 is essential for dendritic integration and network oscillations. Dysfunction or genetic variants of HCN1 are well-established causes of epilepsy and various neurodevelopmental phenotypes, while its cardiac role involves the modulation of sinoatrial node automaticity. |
检测原理