Overview
| 别名 | Hematopoietic prostaglandin D synthase; H-PGDS; GST class-sigma; Glutathione S-transferase; Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; Prostaglandin-H2 D-isomerase |
| 基因名 | HPGDS |
| UniProt ID | O60760 |
| 反应种属 | Human |
| 应用 | IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2P4-R6-K5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 23 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Hematopoietic prostaglandin D synthase (HPGDS) is a bifunctional enzyme encoded by the HPGDS gene located on chromosome 4, primarily involved in the conversion of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2), a crucial mediator in various physiological processes including smooth muscle contraction and immune responses. This enzyme exhibits glutathione transferase activity, utilizing glutathione as a cofactor, and plays a significant role in modulating inflammatory responses, particularly through its anti-inflammatory effects in conditions such as asthma and allergic reactions. Variants of HPGDS have been linked to differential disease susceptibilities, including colorectal cancer risk, highlighting its potential as a therapeutic target. Additionally, HPGDS is expressed in various tissues, particularly in mast cells and antigen-presenting cells, suggesting its involvement in immune regulation and tissue homeostasis. |
检测原理