Overview
| 别名 | Cathepsin L2; Cathepsin U; Cathepsin V |
| 基因名 | CTSV |
| UniProt ID | O60911 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2T9-L7-S5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 37 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Cathepsin V (CTSV), also known as cathepsin L2 or cathepsin U, is a lysosomal cysteine protease belonging to the papain-like protease family (MEROPS family C1) and exhibits endopeptidase activity, primarily functioning in protein degradation within lysosomes. CTSV is notable for its non-canonical localization to the nucleus, where it regulates cell cycle progression and histone stability by modulating the levels of histones H3 and H4 and their chaperone sNASP, highlighting its roles beyond traditional proteolysis. The protein is expressed in various tissues and is upregulated in certain cancers, such as colorectal and breast carcinomas, but not in corresponding normal tissues, suggesting a role in tumorigenesis. Clinically, CTSV has been implicated in the progression of bladder cancer via activation of the NF-κB pathway and may contribute to the pathogenesis of keratoconus. |
检测原理