Overview
| 别名 | Nibrin; Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1; hNbs1 |
| 基因名 | p95 |
| UniProt ID | O60934 |
| 反应种属 | Human |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7S5-P6-D3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 84 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Nibrin (NBN) is a critical protein involved in the cellular response to DNA double-strand breaks (DSBs), functioning as a key component of the MRN (MRE11-RAD50-NBN) complex, which is essential for DNA repair mechanisms. Nibrin plays a pivotal role in recognizing DSBs and facilitating their repair by recruiting other proteins, such as MRE11 and RAD50, to the sites of damage. Nibrin contains several functional domains, including FHA and BRCT domains, which enable it to interact with phosphorylated proteins involved in DNA damage signaling. Beyond its role in DNA repair, nibrin is also implicated in regulating cell cycle checkpoints and maintaining genomic stability. Mutations in the NBN can lead to Nijmegen breakage syndrome, characterized by immunodeficiency, growth retardation, and a heightened risk of cancer due to impaired DNA repair capabilities. |
检测原理