Overview
| 别名 | V-type proton ATPase subunit G 1; V-ATPase subunit G 1; V-ATPase 13 kDa subunit 1; Vacuolar proton pump subunit G 1; Vacuolar proton pump subunit M16 |
| 基因名 | ATP6V1G1 |
| UniProt ID | O75348 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2E8-Z1-A9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 13 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:500-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | ATPase H+ transporting V1 subunit G1 (ATP6V1G1) is a peripheral component of the cytosolic V1 sector of the vacuolar H+-ATPase (V-ATPase) complex. This multisubunit proton pump is responsible for the acidification of intracellular compartments, including endosomes, lysosomes, and secretory vesicles, by coupling ATP hydrolysis to proton translocation across membranes. Such acidification is vital for receptor-mediated endocytosis, protein sorting, and the activation of zymogens. ATP6V1G1 specifically contributes to the assembly and structural integrity of the V1 domain. Clinically, mutations in ATP6V1G1 are genetically linked to optic atrophy 6, a hereditary optic neuropathy, highlighting its essential role in maintaining the homeostasis of specialized neural tissues. |
检测原理