Overview
| 别名 | Ectonucleoside triphosphate diphosphohydrolase 3; NTPDase 3; CD39 antigen-like 3; Ecto-ATP diphosphohydrolase 3; Ecto-ATPDase 3; Ecto-ATPase 3; Ecto-apyrase 3; HB6 |
| 基因名 | ENTPD3 |
| UniProt ID | O75355 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 4X9-V2-F6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 59 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3), also known as CD39L3 or NTPDase-3, is an integral membrane protein encoded by the ENTPD3 gene. It belongs to the E-NTPDase family and hydrolyzes extracellular nucleotides, particularly ATP, ADP, UTP, and UDP, with a threefold preference for ATP and UTP over ADP. ENTPD3 contains four apyrase-conserved regions and is activated by divalent metal ions like Ca²⁺ and Mg²⁺, playing a critical role in purinergic signaling by regulating extracellular nucleotide levels. It is highly expressed in brain, pancreas, spleen, and prostate tissues, where it modulates physiological processes such as insulin secretion in pancreatic β-cells. Structurally, ENTPD3 consists of two major domains with a conserved secondary structure topology, forming a substrate-binding pocket. Dysregulation of ENTPD3 has been implicated in diseases, including cancer, where its activity influences tumor immune evasion and therapeutic responses. |
检测原理