Overview
| 别名 | P antigen family member 1; PAGE-1; AL5; G antigen 9; GAGE-9; G antigen family B member 1; Prostate-associated gene 1 protein |
| 基因名 | PAGE1 |
| UniProt ID | O75459 |
| 反应种属 | Human |
| 应用 | IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4U9-Z6-X4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 16 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:250-1:500; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | PAGE Family Member 1 (PAGE1), encoded by the PAGE1 gene, is a cancer-testis antigen predominantly expressed in normal testicular germ cells and aberrantly activated in various cancers, including melanoma, hepatocellular carcinoma (HCC), and lung cancer. Located on chromosome Xp11.23, PAGE1 belongs to the GAGE/PAGE protein family, which is characterized by germline-specific expression and immunogenic properties. PAGE1 is implicated in immune evasion and apoptosis modulation, potentially promoting tumor survival. In melanoma, PAGE1 overexpression correlates with advanced disease stages and poorer prognosis, suggesting its role in tumor progression. Similarly, in HCC, elevated PAGE1 levels are observed in tumor tissues compared to healthy liver, linking it to oncogenic processes. |
检测原理