Overview
| 别名 | Regulator of G-protein signaling 9; RGS9 |
| 基因名 | RGS9 |
| UniProt ID | O75916 |
| 反应种属 | Human,Mouse |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6J6-R9-R5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 76 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Regulator of G protein signaling 9 (RGS9), encoded by the RGS9 gene, is a GTPase-activating protein (GAP) that accelerates the deactivation of G protein-coupled receptor (GPCR) signaling by enhancing GTP hydrolysis on Gα subunits, thereby terminating downstream signals. It exists in two isoforms: RGS9-1, primarily localized in retinal photoreceptors, and RGS9-2, expressed in the striatum and other brain regions. RGS9 forms obligate complexes with the Gβ5 subunit, which stabilizes the protein, and interacts with tissue-specific partners like R9AP in the retina to regulate phototransduction. In the brain, RGS9-2 modulates dopamine and opioid receptor signaling, influencing neuronal plasticity and reward pathways. Mutations in RGS9 are linked to bradyopsia, a rare retinal disorder characterized by delayed dark adaptation and reduced light sensitivity due to impaired phototransduction kinetics. |
检测原理