Overview
| 别名 | Triacylglycerol hydrolase DDHD2; TAG hydrolase; DDHD domain-containing protein 2; KIAA0725p; Phospholipase DDHD2; SAM; WWE and DDHD domain-containing protein 1; Triglyceride hydrolase DDHD2; Triglyceride lipase |
| 基因名 | DDHD2 |
| UniProt ID | O94830 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1B9-Y5-N3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 81 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | DDHD domain containing 2 (DDHD2) is a multifunctional phospholipase A1 enzyme characterized by sterile-alpha-motif (SAM), WWE, and DDHD domains. It exhibits hydrolase activity toward various lipids, including diacylglycerol, triacylglycerol, and phosphatidic acid, and binds phosphoinositides like PI(3)P for precise membrane targeting. DDHD2 is essential for maintaining neuronal lipid homeostasis and works alongside PNPLA2/ATGL in triacylglycerol catabolism to prevent ectopic lipid accumulation. It also supports membrane trafficking between the endoplasmic reticulum and the Golgi apparatus, ensuring the structural integrity of these organelles. The protein is highly expressed in the cerebral cortex and hippocampus. Biallelic loss-of-function mutations in DDHD2 are the established cause of hereditary spastic paraplegia 54 (SPG54), a neurodegenerative disorder characterized by early-onset lower limb spasticity, intellectual disability, and thin corpus callosum. |
检测原理