Overview
| 别名 | Dickkopf-related protein 1; Dickkopf-1; Dkk-1; hDkk-1; SK |
| 基因名 | DKK1 |
| UniProt ID | O94907 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3F2-V7-X8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 28 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Dickkopf WNT signaling pathway inhibitor 1 (DKK1) is a secreted glycoprotein that acts as a potent antagonist of the canonical Wnt/β-catenin signaling pathway. It contains two cysteine-rich domains and functions by binding to LRP5/6 co-receptors, preventing their interaction with Wnt ligands. DKK1 forms a ternary complex with LRP5/6 and Kremen proteins, promoting internalization of LRP5/6 and further inhibiting Wnt signaling. This protein plays crucial roles in embryonic development, including anterior-posterior axial patterning, limb formation, and somitogenesis. In adults, DKK1 is involved in bone homeostasis and stem cell regulation. Dysregulation of DKK1 has been implicated in various diseases, including cancer, where it can act as both a tumor suppressor and promoter depending on the context. Elevated DKK1 levels have been associated with poor prognosis in several cancer types and bone-related disorders like osteoporosis. |
检测原理