Overview
| 别名 | Neurexophilin-3 |
| 基因名 | NXPH3 |
| UniProt ID | O95157 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6Y6-G7-Z8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 28 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Neurexophilin 3 (NXPH3) is a secreted neuronal glycoprotein that functions as a specific ligand for presynaptic α-neurexins, forming a tight extracellular complex essential for efficient neurotransmitter release. Structurally, NXPH3 contains a signal peptide and mature peptide region and is localized mainly in select neuronal populations such as subplate-derived neurons in cortical layer 6b, granule cells in the vestibulocerebellum, and Cajal-Retzius cells during development. Its expression pattern suggests a modulatory role in synaptic function rather than a universal cofactor for α-neurexins. Functional studies in knockout mice revealed that loss of NXPH3 leads to sensory processing deficits and impaired motor coordination without gross anatomical brain defects, indicating its importance in specific neuronal circuits involved in sensorimotor gating. Clinically, mutations or dysregulation of NXPH3 have been linked to neurodevelopmental disorders such as lissencephaly with complex brainstem malformations and Sjogren-Larsson syndrome. |
检测原理