Overview
| 别名 | Structural maintenance of chromosomes protein 2; SMC protein 2; SMC-2; Chromosome-associated protein E; hCAP-E; XCAP-E homolog |
| 基因名 | SMC2 (acetyl K114) |
| UniProt ID | O95347 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 4M8-A7-O2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 135 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | SMC2 (acetyl K114) refers to a specific acetylation modification on lysine 114 of the Structural Maintenance of Chromosomes 2 (SMC2) protein. SMC2 is a core ATPase subunit of the condensin complex, which is indispensable for chromosome condensation and segregation during cell division. The protein features a hinge and coiled-coil domain structure that facilitates DNA entrapment and compaction. Acetylation at lysine 114 modulates the functional properties of SMC2, influencing its interaction with DNA or other complex subunits. Proper regulation of SMC2 and its post-translational modifications is critical for genomic stability; defects in this machinery are linked to developmental disorders and chromosomal instability in cancer. |
检测原理