Overview
| 别名 | Phosphatidate cytidylyltransferase 2; CDP-DAG synthase 2; CDP-DG synthase 2; CDP-diacylglycerol synthase 2; CDS 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CTP:phosphatidate cytidylyltransferase 2 |
| 基因名 | CDS2 |
| UniProt ID | O95674 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6D5-R6-K8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 51 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | CDP-diacylglycerol synthase 2 (CDS2) is an integral membrane enzyme essential for phosphoinositide and mitochondrial phospholipid metabolism. Localizing to the endoplasmic reticulum and mitochondrial inner membrane, it catalyzes the conversion of phosphatidic acid to CDP-diacylglycerol, a critical intermediate for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. CDS2 exhibits substrate specificity for arachidonyl-containing species and supports lipid droplet maturation, linking lipid synthesis to energy homeostasis. Dysfunction of CDS2 disrupts phospholipid availability in neural and muscular tissues. Pathogenic variants are associated with a syndrome comprising congenital muscular dystrophy, cataracts, and intellectual disability, as well as bilateral temporo-occipital polymicrogyria, highlighting its necessity for neuromuscular and cortical development. |
检测原理