Overview
| 别名 | T-cell leukemia/lymphoma protein 1B; Oncogene TCL-1B; Oncogene TCL1B; SYN-1; Syncytiotrophoblast-specific protein; TCL1/MTCP1-like protein 1 |
| 基因名 | TCL1B |
| UniProt ID | O95988 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5Y5-E6-M8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 14 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | TCL1 family AKT coactivator B (TCL1B), or T-cell leukemia/lymphoma protein 1B, is a protein encoded by the TCL1B gene in humans. It functions as an AKT kinase co-activator, enhancing the phosphorylation and activation of AKT1 and AKT2. TCL1B exhibits protein kinase binding activity and protein serine/threonine kinase activator activity, playing a role in intracellular signal transduction. The protein is involved in positive regulation of peptidyl-serine phosphorylation and protein kinase B signaling. TCL1B is expressed in CD4-/CD8- immature T-cells, pre B-cells, and virgin B-cells, with expression decreasing at more mature stages of B-cell development. Overexpression of TCL1B has been implicated in the development of mature T-cell leukemia, with chromosomal rearrangements bringing the gene in close proximity to T-cell antigen receptor regulatory elements. Additionally, TCL1B has been associated with lymphatic system diseases and immune system disorders. |
检测原理