Overview
| 别名 | Serine protease inhibitor Kazal-type 1; Pancreatic secretory trypsin inhibitor; Tumor-associated trypsin inhibitor; TATI |
| 基因名 | SPINK1 |
| UniProt ID | P00995 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3Z7-I2-A5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 8 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:500-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Serine peptidase inhibitor Kazal type 1 (SPINK1) is a secreted protein that functions as a protease inhibitor, primarily targeting trypsin. It contains 79 amino acids, including a 23-amino acid signal peptide, and features three intramolecular disulfide bridges. SPINK1 is mainly expressed in the pancreas, where it prevents premature activation of digestive enzymes. It also exhibits growth factor-like properties, binding to the epidermal growth factor receptor (EGFR) and activating downstream signaling pathways. SPINK1 plays roles in regulating autophagy and cellular proliferation. Mutations in the SPINK1 gene are associated with chronic pancreatitis and hereditary pancreatitis. Additionally, SPINK1 overexpression has been linked to various cancers, including pancreatic, ovarian, and prostate cancer, where it promotes tumor growth, metastasis, and drug resistance. |
检测原理